Dr. Underhill elucidates modes of tricarboxylic acid uptake

Yes, E. coli and P. aeruginosa are both gamma-proteobacteria. But don't make the mistake of thinking that their metabolic preferences are the same. E. coli loves glucose, but P. aeruginosa would rather eat citrate-cycle intermediates like citrate and aconitate. Despite this preference, little has been known about the uptake mechanisms. New work by Dr. Simon Underhill revises the current model for citrate utilization by P. aeruginosa, showing the importance of the putative TctCBA transporter and identifying new and redundant citrate transporters. His work is in press at Journal of Bacteriology